A human cell type similar to murine central nervous system perivascular fibroblasts

The brain vasculature has several specific features, one of them being the blood-brain barrier (BBB), which supports and protects by allowing for passage oxygen nutrients, while at same time preventing pathogens toxins. BBB also prevents efficient delivery drugs to brain, e.g. treatment tumors. In murine perivascular fibroblasts were recently identified as a novel potential constituent BBB. Here we present existence human cells that could be equivalent fibroblasts. Using RNA sequencing, show similar transcriptomic profile cultured These data open up window new hypotheses on cell types involved in CNS diseases.